A molecular basis for odorant recognition: olfactory receptor pharmacology
نویسندگان
چکیده
منابع مشابه
Odorant receptor specificities and receptor combinatorials: implications for olfactory coding.
The perception and discrimination of thousands of different odorants by the vertebrate olfactory system results from the activation of specific olfactory neurons within the olfactory epithelium of the nose (reviewed in Buck, 2000; Firestein, 2001). Activity from these cells is then interpreted by the brain to discern the molecular identity of a given odorant stimulus. How is this process of mol...
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Different odorants are recognized by different combinations of G protein-coupled olfactory receptors, and thereby, odor identity is determined by a combinatorial receptor code for each odorant. We recently demonstrated that odorants appeared to compete for receptor sites to act as an agonist or an antagonist. Therefore, in natural circumstances where we always perceive a mixture of various odor...
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The olfactory receptor (OR) superfamily provides a basis for the remarkable ability to recognize and discriminate a large number of odorants. In mice, the superfamily includes approximately 1000 members, and they recognize overlapping sets of odorants with distinct affinities and specificities. To address the molecular basis of odor discrimination by the mammalian OR superfamily, we performed f...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2004
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.124.201